Automated CT quantification of interstitial lung abnormality and interstitial lung disease according to the Fleischner Society in patients with resectable lung cancer: prognostic significance
This study investigated the prognostic significance of interstitial lung abnormality (ILA) in non-small-cell lung cancer (NSCLC) patients, using automated CT quantification. Of 1524 patients who underwent surgery for NSCLC, those with ILA and interstitial lung disease (ILD) had significantly poorer recurrence-free survival (RFS) and overall survival (OS) rates. Both fibrotic and non-fibrotic ILA components were associated with worse RFS and OS in both the normal and ILA groups. The study concludes that automated CT quantification of ILA could serve as a valuable predictor of patient outcomes and could aid in decisions regarding active surveillance for disease recurrence.